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Now offering:  Phase I & Pharmacokinetic Unit
Director and Investigator CV's:

Ronald Leonard Brazg, M.D., F.A.C.E.

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RAINIER CLINICAL RESEARCH CENTER
Director and Principal Investigator
 
Office Address
723 SW 10th Street, Suite 100
Renton, Washington 98057
(425) 251-1720 | (425) 251-1723 FAX | Email rcrc@rainier-research.com

Personal

Date of Birth: October 11, 1957

Academic Position

1992- Clinical Assistant Professor of Medicine
Division of Metabolism and Endocrinology
University of Washington, Seattle, Washington.

Postgraduate Training

2003-
 
1990-1992
 
 
1989-1990
 
 
1987-1989
 
 
1986-1987
 
 
1984-1986
 
 
1982-1983
 
 
1980-1981
 
AACE Certification in Thyroid Ultrasound
 
Senior Fellow in Endocrinology and Metabolism
University of Washington, Seattle, Washington
 
Chief Resident and Attending Physician in Internal Medicine
Sinai Hospital, Detroit, Michigan
 
Senior Resident in Internal Medicine
Sinai Hospital, Detroit, Michigan
 
Research Physician--Diabetes Program
Wayne State University, Detroit, Michigan
 
Resident in Internal Medicine
Baragwanath Hospital and University of the Witwatersrand, Johannesburg, South Africa
 
SADF--Mandatory National Service
Rank: Full Lieutenant (medical officer), Family Practice, Internal Medicine and Emergency Medicine.
 
Internship (General Surgery and Internal Medicine)
Hillbrow Hospital and University of the Witwatersrand, Johannesburg, South Africa

Education

1980
 
1974
University of Witwatersrand, Medical School, Johannesburg, South Africa, M.B.B.Ch.
 
Matriculated from Parktown Boys' High School with honors in Math, Physical Science, Latin, and Accountancy

Hospital Positions

1992
 
 
 
1992
 
 
1996-1997
 
 
 
Clinical Assistant Professor
Division of Metabolism & Endocrinology, University of Washington,
Seattle, Washington
 
Medical Staff
Valley Medical Center, Renton, Washington (VMC)
 
Vice Chairman, Department of Medicine VMC
Medical Director – HMR Weight Management Program VMC
Medical Director – Diabetes Education Program VMC

Board Certifications

1993
 
1990
Endocrinology, Diabetes & Metabolism
 
American Board of Internal Medicine

Licensure to Practice

1990
 
1986-1990
State of Washington
 
State of Michigan

Professional Organization Membership

1993-
1992-
1992-
1993-1997
1997-1999
2002
American Diabetes Association
King County Medical Society
Washington State Medical Association
American Heart Association - Past President, Springbrook Division, WA
Valley Physicians Organization – Past Chairman, Contract Committee Member, Value Analysis Committee
American Association of Clinical Endocrinologists Fellow (2003)

Bibliography

  1. Chait A, Brazg RL, and Krauss RM: Increased oxidative susceptibility of LDL subfractions in subjects with the atherogenic lipoprotein phenotype. Arteriosclerosis and Thrombosis 11(5):1425A, 1991.
  2. Brazg RL, Duell PB, Gilmore M, Bierman EL, and Chait A: Effects of dietary antioxidants on LDL oxidation in non-insulin-dependent diabetes. Clin Res 40(1):103A, 1992.
  3. Zambon S, Brazg RL, Aviram M, Oram JF, and Bierman EL: The effect of probucol on HDL-mediated sterol translocation and efflux from cells. Atherosclerosis 94(1):51-60, 1992.
  4. James J. Maciejko, M.S., Ph.D., Ronald Brazg, M.D., Aajay Shah, M.D., et.al.: Psyllium fiber reduces the gastrointestinal symptomatology associated with cholestyramine in the treatment of primary hypercholesterolemia. Arch Fam Med/Vol 1. Sept. 1992.
  5. Chait A, Brazg RL, Tribble DL, and Krauss RM: Susceptibility of small, dense low density lipoproteins to oxidative modification in subjects with the atherogenic lipoprotein phenotype, pattern B. Am. J. Med - 94 (4) 350-356, 1993.
  6. Brazg RL and Bierman EL: Insulin excess counteracts the effects of HDL on intracellular sterol accumulation. Diabetologia, 36:942-947, 1993.
  7. Brazg RL: Is Glycemic control enough to control the dyslipidemia in NIDDM. Clinical Diabetes, 11;117, 1993.
  8. Brazg RL, Decherney S et al; Safety and efficacy of a novel extended release formulation of metformin in patients with Type II Diabetes – A dose-ranging study. Abstr. Diabetes 49; A99, 2000
  9. Insull W Jr, Isaacsohn J, Kwiterovich P, Ra P, Brazg R, Dujovne C, Shan M, Shugrue-Crowley E, Ripa S, Tota R: Efficacy and safety of cerivastatin 0.8 mg in patients with hypercholesterolaemia: the pivotal placebo-controlled clinical trial. Cerivastatin Study Group.
  10. J Int Med Res. 2000 Mar-Apr; 28(2):47-68
  11. J. Isaacsohn, W. Insull, E. Stein, P. Kwiterovich, P. Ma, R. Brazg, C. Dujovne, M. Shan, E. Shurgrue-Crowley, S. Ripa, R. Tota, for the Cerivastatin Study Group. Clin. Cardiol. Vol 24, (Suppl. IV), IV-1-IV-9, 2001
  12. D.B.Hunninghake, M.D.,M.E. McGovern, M.D., M. Koren, M.D., R. Brazg, M.D., D. Murdock, M.D., S. Weiss, M.D., T. Pearson, M.D., Ph.D.: A Dose-Ranging Study of a New, Once-Daily, Dual-Component Drug Product Containing Niacin Extended-Release and Lovastatin. Clinical Cardiology Vol. 26, No. 3, March 2003
  13. Feldman B, Brazg R, Schwartz S, Weinstein R: A continuous glucose sensor based on wired enzyme technology-results from a three day trial in patients with Type 1 diabetes. Diabetes Technol. Ther. 2033: 5(5): 769-779
  14. Ehlers MR, Klaff LJ, D’Alessio DA, Brazg R, Kay HD, Harley RE, Mathisen AL, Schneider R Recombinant glucagons-like peptide-1 (7-36 amide) lowers fasting serum glucose in a broad spectrum of patients with type 2 diabetes. Horm Metab Res. 2003 Oct;35 (10):611-6
  15. K. Fujioka, R.L. Brazg, I. Raz, S. Bruce, S. Joyal, R. Swanink, M.Pans Efficacy, dose-response relationship and safety of once-daily extended-release metformin (Glucophage XR) in type 2 diabetic patients with inadequate glycaemic control despite prior treatment with diet and exercise: results from two double-blind, placebo-controlled studies. Diabetes, Obesity and Metabolism, 7, 2005, 28-39
  16. Julio Rosenstock, MD, Ronald Brazg, MD, Paula J. Andryuk, BS, Kaifeng Lu, PhD, and Peter Stein, MD, for the Sitagliptin Study 019 Group Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazine therapy in patients with Type 2 diabetes: a 24 week, multicenter, randomized, double-blind, placebo-controlled, parallel group study. Clinical Therapeutics/Volume 28, Number 10, 2006
  17. R. Brazg, L. Xu, C. Dalla Man, C. Cobelli, K. Thomas, P.P. Stein Effect of adding sitagliptin, a dipeptidyl peptidase-4 inhibitor, To metformin on 24-hour glycaemic control and b-cell function in patients with type 2 diabetes. Diabetes, Obesity and Metabolism, 9, 2007, 186-193
  18. Weinstein RL, Schwartz SL, Brazg RL, Bugler JR, Peyser TA, McGarraugh GV "Accuracy of the 5-day Freestyle Navigator ® Continuous Glucose Monitoring System: comparison with frequent laboratory reference measurements. Diabetes care. 2007 mar2; [epub ahead of print] pmid: 17337488 [pubmed-as supplied by publisher]
  19. Richard L. Weinstein, MD; Sherwyn L. Schwartz, MD; Ronald L. Brazg, MD; Jolyon R. Bugler, MS; Thomas A. Peyser, Ph.D; Geoffrey V. Mcgarraugh, MS The Freestyle Navigator CGMS: Accuracy. The measures made with the freestyle Navigator were consistent and accurate. Review of Endocrinology. June 2008 Cover Story

Educational

  1. Cell membrane receptors and their modulation by membrane phospholipids in normal and disease states. Diabetes and Obesity. Diabetes Program, Wayne State University, Detroit, MI, 1986-1987.
  2. High density lipoprotein metabolism in human monocytes. Awarded first prize for best scientific presentation, Sinai Hospital, Detroit, MI, 1989-1990.
  3. Honored for Contribution to Medical Education, Sinai Hospital, Detroit, MI, 1989
  4. Excellence in Teaching Award, Valley Medical Center, 1995
  5. Excellence in Teaching Award, Valley Medical Center, 1996
  6. “Best Doctors in America” 2002/2003
  7. “Best Doctors in America” 2003/2004

Clinical Research

1991- present Rainier Clinical Research Center, Inc.
Principal Investigator or Sub-Investigator on over 250 clinical trials
Phase I-IV
 
Revised 9/18/2008 | Back to Top
 
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723 SW 10TH ST, Suite 100
Renton, WA 98057
 
rcrc@rainier-research.com
 
Office: 425-251-1720
Toll Free: 888-478-8343
Fax: 425-251-1723

CURRENT CLINICAL STUDIES

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